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...Merck’s Covid-19 antiviral pill failed to show it can lower the risks of hospitalisation and death among adults at higher risk from the disease, according to the results of a pivotal clinical trial in the...
...Clinical trials found that the medication, which requires monthly infusions to remove amyloid-beta proteins from patients’ brains, had an even higher incidence of brain swelling....
...Shah also wants Novavax to strike royalties partnerships to access outside funding to restart clinical studies into other vaccines targeting influenza, respiratory syncytial virus and H5N1 bird flu....
...times its earnings before interest, tax, depreciation and amortisation — also worries some market participants who believe the company may face unmet financial obligations or cash flow problems before its clinical...
...Vertex hopes to receive US Food and Drug Administration approval for a non-opioid painkiller, known as VX-548, this year after a late-stage clinical study showed it lowered pain with a far lower incidence...
...These orders were visible to the rest of the market, the complaint alleged, which led other investors to dump the shares, hammering NWBO’s valuation even as a key clinical trial yielded impressive results...
...“Merck and Pfizer did not conduct new clinical trials to check that their drugs were still effective,” he said, with original trials only showing “marginal benefits”....
...Shares in Pfizer fell 5 per cent in in New York on Friday after the group said more than half of the participants in its clinical trial for the new drug had dropped out because of side effects....
...But since the pandemic, it has been criticised for falling behind and causing delays for commercial clinical trials....
...Merck told the FT on Monday that the study had limitations that the authors themselves had acknowledged and that it was “confident” in the clinical profile of the drug....
...In a phase 2b trial of patients with moderate to severe ulcerative colitis, a type of IBD, it improved clinical remission by 36 per cent in 56 weeks, compared with placebo....
...He said chancellor Jeremy Hunt and the health department should address conflicts with the pharmaceutical industry over drug prices and hurdles to running clinical trials in the NHS....
...The second was Permira’s takeover of clinical testing group Ergomed for £703mn....
...Prosecutors and the SEC alleged that a former Pfizer staff member who was privy to early positive data from the clinical trials of the Paxlovid antiviral Covid-19 treatment had bought short-term call options...
...Last month, the FDA’s panel of experts unanimously voted that Leqembi does show “clinical benefit”....
...“If you can’t get those M&A [deals] and then get those molecules distributed across the globe, it stifles innovation for sure,” said Pao, who heads the Pfizer arm responsible for clinical development of...
...Almost two dozen clinical trials on drugs seeking to treat Alzheimer’s by reducing these plaques have failed since 2003, prompting scepticism among some experts that removing amyloid can slow progression...
...The group already has 24 approved cancer medicines, and 33 programmes in clinical development. Shares in Pfizer fell 2.9 per cent to $38.25 in pre-market trading on Monday before closing at $39.86....
...Grail is forecast to lose $670mn in 2023 as it funds the largest-ever clinical study of a multicancer detection test in the UK....
...The new collective said it would push for new rules for big tech companies to provide workers with access to independent, 24-hour clinical support....
...However, the presentation of the DCVax clinical data was not well received by all commentators....
...The success of lecanemab’s clinical trial ought to encourage other projects to remove amyloid deposits from the brain....
...granting Aduhelm, Biogen’s Alzheimer’s drug, accelerated approval in 2021 despite an internal advisory committee’s refusal to issue a favourable recommendation, and concerns about the drug’s inconsistent clinical...
...Dementia drug candidates still have one of the highest failure rates in clinical development — 97 per cent according to one study....
...Ahead of the release of detailed information on Eisai’s new drug lecanemab, developed with Biogen, the company’s share price surged 60 per cent after results of a late-stage clinical trial showed that it...
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