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...T-cells are a type of white blood cell that play a disease-fighting role in the human immune system....
...Japan’s sovereign development bank is investing in UK life sciences for the first time with funding for 4Bio Capital, a UK venture fund that backs advanced treatments such as cell and gene therapies....
...“If it works, it’s ‘one and done’” but the cost to health systems “is something that worries me”, he added, noting that gene therapies could be priced in “the million dollar range” per patient....
...Corporation of China, a major state-owned defence and aerospace group....
...“Biology is a dynamic system and you have to understand how properties of biology emerge through the interaction between different molecules in the cells,” said Sir Demis Hassabis, DeepMind’s chief executive...
...“It’s a new paradigm in how to understand these conditions and develop drugs,” said Sergiu Pașca, project leader and Stanford’s professor of psychiatry and behavioural sciences....
...Casgevy involves taking stem cells from patients’ bone marrow, editing them in a laboratory and transplanting them back into the patient.The process is prohibitively expensive for many health systems....
...Lenmeldy works by inserting a genetically modified version of the gene that causes MLD in a patient’s blood stem cells and delivering it via an infusion....
...Last November, the UK became the first country to approve a treatment using Crispr technology, based on the bacterial immune system, for sickle cell disease....
...“We have very good surveillance systems in high-income countries,” he points out. “So we’re able to detect [and] respond to those outbreaks.”...
...But paradigms in science are infamously stubborn: many have undoubtedly clung too long to a DNA-centric model, causing wasted efforts in science and medicine — and perhaps more bizarre things too....
...And these preventive treatments are becoming ever more important, as health systems strain under the weight of ageing populations and increasing levels of chronic disease....
...The researchers found that Covid-19 infection triggered IFN-γ production by white blood cells — and this persisted in the long Covid patient cohort....
...Other companies are developing therapies based on Crispr, which is based on the bacterial immune system....
...using a so-called brain organoid — a small three-dimensional neural structure grown from human stem cells....
...This suggests sufferers’ immune systems “rev up” to the point where they move from protect to attack mode, weakening healthy cells....
...Crispr is a flexible and efficient gene editing tool based on the bacterial immune system, which has sped from the initial discovery to an approved drug in just 11 years....
...This is a perfect example of the immense complexity of biological systems, and the countless trade-offs our bodies must make every day....
...And science can — and should — be used to encourage international co-operation....
...To test a drug, Quantiphi first administers the drug to human cells. Then a digital microscope takes images which the AI system can use to analyse and count the number of dead and living cells....
...Analysts say that one of Wang’s most important achievements came in 2022 when BYD cracked “cell-to-body”, or “cell-to-chassis”, technology....
...attack healthy recipient cells....
...Developing drugs that can also tackle illnesses associated with obesity is key to convincing more health systems to pay for them....
...It also funds research on stem cell science and climate change and gives to humanitarian causes, such as providing shelters and essential medicines to Ukraine....
...suppressing the whole immune system....
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