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...Vertex hopes to receive US Food and Drug Administration approval for a non-opioid painkiller, known as VX-548, this year after a late-stage clinical study showed it lowered pain with a far lower incidence...
...Merck’s Covid-19 antiviral pill failed to show it can lower the risks of hospitalisation and death among adults at higher risk from the disease, according to the results of a pivotal clinical trial in the...
...Shares in Pfizer fell 5 per cent in in New York on Friday after the group said more than half of the participants in its clinical trial for the new drug had dropped out because of side effects....
...Andrew Hill, a senior visiting research fellow at Liverpool university’s pharmacology and therapeutics department, said the drug also had potential side effects for pregnant women....
...Merck’s research chief has called on the UK government to make the country more welcoming to pharma companies, ahead of the US-based drugmaker breaking ground on a £1bn research centre in London next week...
...In a phase 2b trial of patients with moderate to severe ulcerative colitis, a type of IBD, it improved clinical remission by 36 per cent in 56 weeks, compared with placebo....
...There is no evidence from randomised trials that either molnupiravir or Paxlovid will [still] be effective, now that most people have been either vaccinated or infected,” said Andy Hill, a senior visiting research...
...Last month, the FDA’s panel of experts unanimously voted that Leqembi does show “clinical benefit”....
...Almost two dozen clinical trials on drugs seeking to treat Alzheimer’s by reducing these plaques have failed since 2003, prompting scepticism among some experts that removing amyloid can slow progression...
...Grail is forecast to lose $670mn in 2023 as it funds the largest-ever clinical study of a multicancer detection test in the UK....
...A healthy flow of future drugs that could make a real impact on Alzheimer’s and other forms of dementia will depend on nourishing the scientific roots of research and then helping promising projects across...
...Dementia drug candidates still have one of the highest failure rates in clinical development — 97 per cent according to one study....
...It licensed lecanemab in 2007 from a small Swedish biotech, BioArctic, which it continues to work closely with on research....
...It’s a habit that they learn,” said Joel Neutel, principal investigator on the Amgen clinical trial....
...The clinical trial forms part of a six-year collaboration between Merck and Moderna in the field of developing personalised cancer vaccines....
...Despite the controversy over Aduhelm, Carrillo said it was an encouraging time for Alzheimer’s research, pointing to increased government funding and key findings from clinical trials....
...Mind-expanding treatments are a burgeoning area of medical research and venture capital investment....
...Brian Dickie, director of research at the MND Association, the UK patients’ charity, said: “These latest results provide mounting confidence that tofersen is having both a biological and a beneficial clinical...
...Molnupiravir, the antiviral pill developed by Merck to treat Covid-19, speeded up patients’ recovery but failed to reduce risks of hospitalisation and death, full results of an extensive UK clinical trial...
...Eric Topol, founder and director of the Scripps Research Translational Institute, said the companies should provide evidence of a neutralising antibody response, which could be generated easily and quickly...
...AstraZeneca is increasing its spending on research and development partly to fund more trials to see whether Enhertu can tackle other cancer types....
...research and development, told the Financial Times....
...Takeki Uehara, vice-president of Shionogi’s clinical research department, said its different structure means it stays in the body for much longer and does not need to be taken with ritonavir....
...J&J expects to publish late-stage clinical data for its vaccine in the coming months as does Moderna, which is aiming to develop a single “multivalent” jab that would protect against RSV, influenza and Covid...
...Pfizer said it would make a $25mn milestone payment to Valneva on initiation of the phase 3 clinical study....
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