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...The University of Oxford spinout is pushing genetic testing beyond the search for individual genes, looking at how combinations of genes increase people’s likelihood of developing diseases such as cancer...
...Oxford BioMedica raised earnings guidance for next year as the Covid-19 vaccine manufacturer signs new clients for its cell and gene therapy business, sending shares up as much as 20 per cent....
...The Cambridge group’s work has started to “open up a door into almost unlimited reprogramming in biology”, said Ben Davis, a professor of chemical biology at Oxford university....
...Research using Biobank data has already helped identify genes offering protection against obesity and diabetes, as well as others that raise risks of heart disease, breast cancer and prostate cancer....
...UK gambling group Entain has appointed Ricky Sandler, who runs the US hedge fund Eminence Capital, to its board. Eminence is one of Entain’s largest activist investors....
...Clinical trials of the first AI-designed molecule — announced in 2020 by Oxford-based Exscientia and Sumitomo Pharma — were unsuccessful....
...AstraZeneca also announced its plan to acquire Pfizer’s early stage portfolio of gene therapies, in a deal worth up to $1bn, plus royalties on future sales....
...Muralidhar said the Potters Bar site, situated at the centre of the so-called Golden Triangle for life sciences, between Oxford, Cambridge and London, could bolster the UK’s cell and gene therapy industry...
...The company is now expanding into clinical markets, creating same-day tests for important genes, such as those that indicate a higher risk of breast cancer....
...Join the dots: technologies like AI or gene editing cut across multiple different regulators (you need to consult 11 to put a satellite into space, for example) so in a modern economy regulators have to...
...For gene editing, read A Crack in Creation (2018) by the Nobel laureate Jennifer Doudna....
...“The concept of first using an isolated organ to identify the genes associated with disease and then silencing those genes through siRNA before going into clinical trials seems to me extremely elegant.”...
...Brussels has proposed loosening restrictions on some gene-edited crops....
...He recalls the sale of Cambridge-based gene sequencing company Solexa to the US company Illumina in 2007 for $600mn....
...The specialist pharmaceutical manufacturer, which also makes cell and gene therapies, will make its Oxbox facility available on an “as needed” basis to AstraZeneca after 2022....
...The project aims to create an injectable cure using “ultra-specific” gene therapy technology that could “silence”, or edit, genes that cause inherited cardiac conditions....
...Hill is more upbeat about gene drives that could kill off the mosquitoes that spread malaria. But “it makes a big difference whether [they work in] 50 years’ time or five years’ time.”...
...People with the gene ApoE4 appear particularly vulnerable....
...These ancient gene patterns have physiological and medical implications today, affecting for example how the human immune system responds to infection....
...Oxford BioMedica — which also manufactures components of cell and gene therapies — forecast that total revenues this year would be lower than in 2021, when they were boosted by large deals to manufacture...
...Foundation is to spend $200mn developing what it says will be the first practical quantum computer for life sciences research, with applications ranging from creating new medicines to finding links between genes...
...poles of the Huxleys’ curricula vitae, An Intimate History of Evolution is also a biography of ideas, using one family’s history to explore the development of theories about generations, genealogy and genes...
...Thousands of genes must be switched on and off in a specific order....
...This involves thousands of genes being switched on and off in a specific order....
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