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...Since then, new immunotherapy drugs have pushed back cancer and mRNA vaccines have ended a pandemic. Japan’s Eisai and Eli Lilly of the US are now making progress against Alzheimer’s disease....
...Drug developers have pushed cancer into retreat with immunotherapy medicines....
...Merck’s cancer immunotherapy Keytruda is a wonder drug that has transformed not just the survival odds of thousands of patients but also the pharmaceutical company’s fortunes....
...Two House committees are investigating a controversial decision by the US Food and Drug Administration to approve a new Alzheimer’s drug called Aduhelm that has had mixed results and yet costs $56,000 a...
...A long list of human illnesses can be accounted for by mutated DNA, including haemophilia, Parkinson’s and possibly Alzheimer’s....
...“Merck is running more studies of a single cancer immunotherapy drug than are taking place in the entire field of Alzheimer’s”....
...Rebalancing the system might stop Alzheimer’s in its tracks or even reverse it by removing unwanted proteins....
...We did not anticipate that it would find potential success using blood albumin to capture one of the proteins identified in the brains of Alzheimer’s patients....
...“The Car-T technology is moving very quickly,” says Peter Lebowitz, global head of oncology at Janssen, the drugmaking unit of Johnson & Johnson....
...Discovering new drugs is getting harder, added Jennifer Taubert, executive vice-president at Janssen Pharmaceuticals, the drugmaking division of J&J. “The easy diseases have largely been solved....
...Since then other partnerships have been announced, including agreements with Janssen, a pharmaceutical arm of Johnson & Johnson, and AstraZeneca....
...There are opportunities in a number of areas where sex differences have already been well documented — for instance, in diseases linked to metabolism, such as diabetes, cardiovascular diseases, Alzheimer...
...The deal is a sign that drugmakers such as AbbVie hope to bring rapid advances made in cancer immunotherapy to neurodegenerative diseases such as Alzheimer’s by encouraging the immune system to halt the...
...Last week, Prothena in the US, which has been developing drugs to treat degenerative diseases such as Alzheimer’s, revealed a key project had flunked tests and its shares fell by two-thirds....
...DDF’s first investment, California-based Alector, last month announced a $225m deal with AbbVie, the US pharmaceutical group, to develop immunotherapies for Alzheimer’s....
...Click here to find out how Denali and Alector are developing drugs to encourage the body’s own immune system to tackle Alzheimer’s, much like immunotherapies have been used to fight cancer with considerable...
...DDF’s first investment, California-based Alector, last month announced a $225m deal with AbbVie, the US pharmaceutical group, to develop immunotherapies for dementia....
...tweeted Brad Loncar, founder of the Loncar Cancer Immunotherapy Exchange Traded Fund....
...Similarly, many think Merck would be unwise to buy Incyte before seeing results from trials of its immunotherapy medicine....
...“The clinical data looked superior to anything else we’d seen,” says Peter Lebowitz, who heads up oncology research at Janssen, J&J’s drugmaking division. “The data were almost too good to believe.”...
...In the months before he took the top job, scientists at the drugmaker had become increasingly confident that its experimental Alzheimer’s drug, Solanezumab, would succeed in late-stage clinical trials....
...Mr Disley says the company can help address “the biggest problem with modern healthcare”: an ageing population, suffering from diseases such as Alzheimer’s, which have a genetic basis....
...Eli Lilly reports on Tuesday and investors will want to know whether it plans to continue developing Solanezumab, an Alzheimer’s drug that recently flunked a late-stage trial....
...denotes Mr Saunders’ intention to focus on a string of individual deals that will grow the company’s existing franchises, including dermatology, eyecare, and diseases of the central nervous system such as Alzheimer...
...“The science in immunotherapy is incredibly profound and the impact nothing short of amazing,” he says....
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